tert-butyl hexahydro-3-oxo-1h-1,4-diazepine-1-carboxylate
1-Boc-3-oxo-1,4-diazepane
CAS: 179686-38-5
Molecular Formula: C10H18N2O3
tert-butyl hexahydro-3-oxo-1h-1,4-diazepine-1-carboxylate - Names and Identifiers
| Name | 1-Boc-3-oxo-1,4-diazepane |
| Synonyms | 1-Boc-3-oxo-1,4-diazepane 1-Boc-3-oxohoMopiperazine 1-Boc-3-Oxo-1,4-diazepane tert-butyl 3-oxo-1,4-diazepane-1-carboxylate 3-Oxo-[1,4]diazepane-1-carboxylic acid tert-butyl ester tert-Butyl Hexahydro-3-oxo-1H-1,4-diazepine-1-carboxylate tert-butyl hexahydro-3-oxo-1h-1,4-diazepine-1-carboxylate 1H-1,4-Diazepine-1-carboxylic acid, hexahydro-3-oxo-, 1,1-dimethylethyl ester |
| CAS | 179686-38-5 |
| InChI | InChI=1S/C10H18N2O3/c1-10(2,3)15-9(14)12-6-4-5-11-8(13)7-12/h4-7H2,1-3H3,(H,11,13) |
tert-butyl hexahydro-3-oxo-1h-1,4-diazepine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H18N2O3 |
| Molar Mass | 214.26 |
| Density | 1.098 |
| Boling Point | 373.1±35.0 °C(Predicted) |
| pKa | 15.56±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
tert-butyl hexahydro-3-oxo-1h-1,4-diazepine-1-carboxylate - Introduction
1-Boc-3-oxo-1,4-diazepane, also known as Boc-Dh-OH, is an organic compound. Its chemical formula is C9H19NO2 and its molecular weight is 173.25g/mol.
Nature:
1-Boc-3-oxo-1,4-diazepane is a white solid with a melting point of about 85-88 degrees Celsius. It is insoluble in water, but can be dissolved in common organic solvents such as ethanol, dimethylformamide and methanol.
Use:
1-Boc-3-oxo-1,4-diazepane is commonly used as a protecting group in organic synthesis. It protects the amino group from unwanted changes in the reaction. In the synthesis, once the target reaction is complete, the Boc protecting group can be removed by appropriate conditions.
Method:
1-Boc-3-oxo-1,4-diazepane can be synthesized by the following steps:
1. React with amino compounds (such as methylamine) to generate Boc protected derivatives of amino compounds.
2. The Boc protected derivative is reacted with a carbonyl compound (such as diethyl carbonate) under alkaline conditions to generate the target compound.
Safety Information:
1-Boc-3-oxo-1,4-diazepane is less dangerous under regular conditions of use. However, it may cause irritation to the eyes and skin, so wear appropriate personal protective equipment such as gloves and goggles when handling. In addition, it should be operated in a well-ventilated place to avoid inhaling its vapor.
Nature:
1-Boc-3-oxo-1,4-diazepane is a white solid with a melting point of about 85-88 degrees Celsius. It is insoluble in water, but can be dissolved in common organic solvents such as ethanol, dimethylformamide and methanol.
Use:
1-Boc-3-oxo-1,4-diazepane is commonly used as a protecting group in organic synthesis. It protects the amino group from unwanted changes in the reaction. In the synthesis, once the target reaction is complete, the Boc protecting group can be removed by appropriate conditions.
Method:
1-Boc-3-oxo-1,4-diazepane can be synthesized by the following steps:
1. React with amino compounds (such as methylamine) to generate Boc protected derivatives of amino compounds.
2. The Boc protected derivative is reacted with a carbonyl compound (such as diethyl carbonate) under alkaline conditions to generate the target compound.
Safety Information:
1-Boc-3-oxo-1,4-diazepane is less dangerous under regular conditions of use. However, it may cause irritation to the eyes and skin, so wear appropriate personal protective equipment such as gloves and goggles when handling. In addition, it should be operated in a well-ventilated place to avoid inhaling its vapor.
Last Update：2024-04-10 22:29:15
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CAS: 179686-38-5
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